Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in world. Although many immunosuppressant biological drugs have been used for UC treatment, cure rate is still very low. It necessary to find some safe long-term medicine cure. Recently, Chinese traditional herb Danshen investigated treatment of UC. However, it limitation that active components are not easily absorbed by human body. Probiotics could convert macromolecules into smaller molecules facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) Bacillus subtillis Natto (F-A7-1) were screened ferment this study. The fermented products gavaged dextran sulfate sodium (DSS)-induced model mice. had better results attenuate symptoms DSS-induced after with F-B4-1 F-A7-1. Loss body weight disease activity index (DAI) reduced. abnormally short colon lengths colonic damage recovered. And inhibitory effect than itself on pro-inflammatory cytokine expression during indicated compared Danshen, relieved mice more effectively. probiotics might be an effective clinic stage future.